ArQule initiates enrollment in ARQ 736 Phase 1 clinical trial for advanced solid tumors ArQule.

ARQ 736 is an ATP-competitive pan-RAF kinase inhibitor developed and discovered at ArQule. This substance has been shown pre-clinically to become a potent inhibitor of mutant BRAF , wild-type BRAF and c-RAF. The main objective of this trial is to measure the protection and tolerability of ARQ 736 in patients with advanced solid tumors that contain BRAF mutations. Additional goals include evaluation of pharmacodynamic and pharmacokinetic profiles in cancer sufferers, in addition to preliminary proof anti-tumor activity and a recommended Phase 2 dose.. ArQule initiates enrollment in ARQ 736 Phase 1 clinical trial for advanced solid tumors ArQule, Inc. today announced the commencement of individual dosing in a Stage 1 scientific trial with ARQ 736, a small molecule inhibitor of the RAF kinases.This will be vacation number nine this complete year for Michelle, the most relaxed First Lady in history. Remember Just, when Obama says he supports the working guy, he doesn’t indicate you, or me. He means the unions are backed by him, who are now fleecing the public in a manner that Jimmy Hoffa never even imagined. I could hear him just, ‘. And all this stuff they convicted me of. Now, it’s most legal!’ Whenever I hear Democrats discuss money, I always remember what some witty scalawag stated many years ago. ‘John D. Rockefeller acquired a shipload of money, more than most of us can imagine.

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