NCS inhibited histamine release only immediately after treatment.

NCS inhibited histamine release only immediately after treatment, but it inhibited delayed tumor necrosis factor? share, even if given after the induction of the inflammatory response.. Boucher and employees of Boston and Dallas examined the effect of intravesical NCS in an established model of cystitis with protamine sulfate and lipopolysaccharide in the rat. The results showed that short intravesical treatment with 1 percent NCS significantly decreased protamine / lipopolysaccharide -induced urinary histamine, bladder explant tumor necrosis factor – and bladder including mast cell accumulation and degranulation.

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