Purdue Birck Nanotechnology Center at the University of Discovery Park.

The tools are needed for demanding models and simulations are provided accommodated with computer cluster that are equivalent to 100 PCs through the nanoHUB, Purdue Birck Nanotechnology Center at the University of Discovery Park.

RNA was once considered just blown the faithful messenger under genetic information from the genome to the ribosome or protein factory, but this view has been removed by recent research. It is now known that RNA has additional roles in the regulation of gene expression and as an important component of both the nucleus and in the ribosome. Moreover, errors in the transcription of RNA from DNA frequently and require a variety of complex mechanisms for quality control of both mis – regulation of genes and the production of aberrant RNA and protein fragments that clog to prevent the functioning of the cell, and that, if disabled can lead to a number of diseases, including cancer..Scientist at Karolinska Institutet in Stockholm have now shown by studies in mice that changes to the mtDNA can Ageing Designed by the introduction fault into proteins of mitochondria. Examining levels of protein is normal, but the proteins rendered unstable quick decompose, eventually leading to the the collapse of cellular respiration. – Our results show that premature aging through mutations in the mtDNA , which be likely to cause to mitochondrial proteins unstable and decompose , Aleksandra Trifunovic, one of the scientists participated in the study says.

‘random point mutations having major effect on protein-coding genes the driving force behind behind Premature Aging in mitochondrial DNA a mutator Mice’Daniel Edgar, Irina Shabalina, Yolanda Camara, Ann Wrede Mount, Marie Antoinette Calvaruso, Leo Nijtmans , Jan Nedergaard, Barbara Cannonball ran Larsson and Aleksandra Trifunovic, Cell Metabolism, August 2009.

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